Avaliação da qualidade de medicamentos hipoglicemiantes dispensados na farmácia municipal de Santa Cruz do Sul : RS.

Abstract

In order to rationalize the resources of health and ensure access to medicines, they are created drug policies which proposes the development of the municipal list of essential drugs (REMUME) which are included only drugs required to meet most health problems of the regional population, with proven safety, efficacy and quality. Among the health issues included in the national health policy is the Diabetes Mellitus that affects a significant number of individuals. The DM needs to be regulated and controlled by a specific diet accompanied by physical activity and the use of hypoglycemic drugs. Pharmacological treatment is essential to reduce morbidity and mortality is essential that the pharmacological effect is preserved and toxicity keep up at appropriate levels from manufacture until use by the patient. The effectiveness of a medicine may be given by the evaluation of its quality using different analytical methodologies to verifying whether the product complies with the specifications laid down for the same. The goal of this study was to evaluate the quality of hypoglycemic drugs Glibenclamide 5 mg / cp and Metformin 850 mg / cp dispensed to users of the Municipal Pharmacy from the City of Santa Cruz do Sul - RS. They were performed testing average weight, hardness, disintegration, friability, identification, assay and uniformity of unit doses. The results confirmed the quality of the drug Metformin 850 mg / cp showing compliance with the pharmacopoeic specifications in all tests. The drug Glibenclamide 5 mg / cp failed the assessment of uniformity of dosage units presenting significant variability between doses compromising the uniformity of these. In other tests the drug has been approved. These data indicate the need to implement strategies whose purpose implies the possibility of buying quality products combined with cost reduction.