Frequência de mucosite oral no serviço de referência oncológica da 13ª CRS.

Abstract

Oral mucositis is an inflammation of the oral mucosa, of multifactorial etiology, but greatly related to oncological chemotherapy or radiotherapy. This side effect, when related to chemotherapy of neoplastic diseases, depends on the agents of drugs, the frequency of treatment and duration of the same. This study aimed at identifying which drugs are used at the oncology reference center of the 13th Regional Coordination of Health (CRS) and their direct relation with the appearance of oral mucositis. On this analytical cross-sectional study, participated 102 patients undergoing chemotherapy for any type of malignant neoplasms, selected through the clinical protocol. Only those patients under therapy with possible causative agents of oral mucositis, through complications identified by the own chemotherapy drugs manufacturers, were interviewed. The statistical analysis was performed by using the program Statistical Package for Social Sciences (SPSS), version 20.0 (Chicago, IL). For associations between the variables and their outcome, it was conducted the Chi-square test. The level of significance was p<0,05. The drugs used on the treatment of patients who presented oral mucositis were grouped by means of their mechanism of action. Among the four groups analyzed, those classified as cycle-specific had a tendency to develop oral mucositis. Oral mucositis was identified in only 7,8% of participants and there was no significant association between the appearance of oral mucositis and the antineoplastic chemotherapy agents. It was possible to conclude that there was also a significant association between absence of present mucositis, identified in the interview, with episodes reported in the past of oral mucositis (p <0,01) and significant association between absence of oral mucositis and malignant neoplasm of breast (p = 0,006).