Avaliação de prescrições de antimicrobianos e suas interações medicamentosas em pacientes da unidade de terapia intensiva neopediátrica de um hospital de ensino.

Abstract

Drug interaction (DI) is a phenomenon that occurs when the effects of a drug are modified due to the co-administration of another drug or food. Such interaction may result in the decrease, increase and / or loss of efficacy of one of the drugs. Patients admitted to the Neopedriatic Intensive Care Unit (ICU) use several medications, which may be more likely to trigger potential interactions. The study aimed to evaluate the drug interactions that most affect the patients hospitalized in Neopedriatic ICU of a teaching hospital located in the city of Santa Cruz do Sul. The methodology was based on a quantitative cross-sectional and descriptive research. The study population consisted of hospitalized patients from January to December 2016. A total of 206 medical records were analyzed, 112 (54,3%) were male patients. The age range of the patients varied from newborn to 11 years and 5 months. Of the total, 50,4% used antimicrobial, and 37,8% used 1 to 3 medications and 80,7% had some type of drug interaction. The highest prevalence of drug interaction was moderate. Ampicillin and Gentamicin were the moderate interaction that occurred more frequently, 75%. It was concluded through this that even with the ease of access to information the prevalence of DI is still high, but with the close collaboration between a multiprofessional team, in particular doctors and clinical pharmacists, this may change over time, identifying the profile of prescriptions and allowing the exchange of medications that in association would bring injury to the patient.