Avaliação da ingestão de vitamina D e cálcio em indivíduos pré-diabéticos e sua relação com a estabilidade genômica.

Abstract

The objective this study is evaluate the vitamin D and calcium intake in prediabetes individuals and their relationship with genomic stability. Vitamin D and calcium intake was determined in DietWin® software and the assessment prevalence of nutrients was classified according to the Dietary Reference Intakes (DRIs) guidelines. The cytokinesis-block micronucleus (CBMN) assay and Comet assay were used to evaluate the genomic stability. The prevalence of vitamin D and calcium inadequate intake were of 94.1% and 86.3%, respectively. Vitamin D intake was associated with calcium consumption (r=0.665 e p<0.0001) and both nutrients were associated with fasting glucose (p<0.05). According to CBMN assay, calcium intake only was associated with the nuclear buds frequency (r=-0.301 e p=0.037). Thus, we can conclude that there are a high prevalence of vitamin D and calcium inadequate. In addction, both nutrients had little influence on genomic instability, observing that only insufficient calcium intake shown has been related to frequency of nuclear buds.