Uso de um enxaguatório bucal com extratos fitoterápicos de mentha piperita, pimpinella anisum e citrus limon, no tratamento de candidíase oral : uma avaliação in vivo.

Abstract

Considered the most common oral fungal infection, candidiasis is usually asymptomatic, but may cause pain, burning and itching, usually presenting as white or erythematous forms, being in pathogenesis is associated with approximately 20 Candida species, but the most frequently isolated is Candida albicans. The diagnosis is usually made clinically, and its onset is related to several factors, such as immunosuppressed states or endocrine dysfunctions, such as diabetes. For its treatment it is important to eliminate the causes or risk factors, which are mainly associated with the use of dental prostheses, as well as the adoption of good oral hygiene. In symptomatic cases, drug treatment is necessary, using antifungal agents such as nystatin oral suspension or the use of 0.12% chlorhexidine mouthwash. The need for the introduction of new options for drug therapies has been justified by the increasing number of cases of clinical resistance, where plant extracts have become an option for treatments due to their numerous activities, including antifungal, conferred by their phenol, flavonoid, coumarins, quinones, saponins, xanthones, alkaloids, terpenoids. Mouthwashes are considered important tools for oral microbiota control, making it possible to gather various antifungal agents in their formulations. The aim of this study was to develop a mouthwash containing the combination of herbal extracts of Mentha piperita, Pimpinella anisum and Citrus limon and to evaluate its therapeutic action in selected volunteers with active oral candidiasis. The water-based mouthwash was subjected to physicochemical, microbiological and stability tests and its use by volunteers after approval by CEP-UNISC under opinion no. 3,492,235 lasted 15 days, and the results were monitored on the 7th and 15th day of treatment, measuring the evolution of the lesions and performing photographic recording. The formulation obtained was stable, maintaining its organoleptic characteristics and pH value without significant change (p <0.05) after preliminary and accelerated stability tests as well as microbiological analyzes. Of those selected, four volunteers completed the study, one with pseudomembranous candidiasis and three with erythematous candidiasis. Improvement was observed in all cases, both in pseudomembranous form, with total reduction of white lesions, as in erythematosus, with reduction of reddish tone of the lesions, evidencing the antifungal potential of the extracts used.