Avaliação da severidade dos sintomas em pacientes com SARSs CoV-2 e de sua relação com o comprimento dos telômeros.

Abstract

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a public health crisis worldwide. The clinical manifestations and severity of symptoms are slowly being clarified, however, it is already known that severity increases with age, with older people having higher mortality, suggesting that molecular pathways underlying aging contribute to the severity of Covid-19. Telomeres are structures that are located at the ends of chromosomes and are being widely investigated, the length of which is related to inflammatory processes and biological age. The Covid-19 virus, SARS-CoV-2 can infect many different types of cells, causing the process of tissue regeneration and renewal to increase. Studies have indicated a relationship between Covid-19 and telomere length, and the size of this structure may have implications for disease severity.Based on this, the objective of the study is to evaluate the severity of symptoms in people who have been infected with the SARS-CoV-2 virus and the relationship with telomere length, in order to understand the severity and gravity of the disease in individuals with shorter telomeres. The study included people who had been infected with SARS-CoV-2, whose symptoms were severe, mild, or asymptomatic. The analyses were performed on 67 participants, of which 36 (53.7%) had already taken some dose of the vaccine. Most participants were in the age range of 21-40 years (43.3%). From the participants analyzed, all showed at least some type of symptom, with the most prevalent symptom being fatigue, presented by 59 (88%) people and the least prevalent was cutaneous eruption 11(16.4%). In addition, the participants were mostly shown to have shortened telomeres 38(56.7%). From this study, it was possible to advance the understanding of why some develop the severe forms of Covid-19 and others do not and explaining some unique epidemiological aspects of the SARS-COV-2 pandemic and its relationship to telomere length.