Desenvolvimento de formulações tópicas labiais contendo mentha x piperita (l) : avaliação sensorial e físico-química.

Abstract

Lip topical formulations are intended for application to the skin or certain mucous membranes. Lipsticks and lip balms are topical formulations intended for application to the lips only. Mentha x piperita L. is the plant from which peppermint essential oil is extracted, commonly used in the pharmaceutical and cosmetic industry for the treatment of various diseases. Its highest concentration compounds are menthol and menthone, and in lower concentrations other terpenes such as Neo-menthol, D limonene and isomenthone. It has proven antiseptic, antibacterial and antiviral properties. The objective of this work was to develop and evaluate the appearance and physical-chemical characteristics of topical lip formulations containing essential oil of peppermint, where through the conduction of studies of accelerated stability and preliminary stability by ice-thaw cycle, it was sought to evaluate the viability of incorporating OEHP in obtaining pharmaceutical formulations for lip application (lipsticks and lip balms). Peppermint essential oil was characterized by gas chromatography with mass spectrometry (GC-MS) of commercial pure OEHP and OEHP extracted from the formulation after stability tests. The lipsticks and lip balm did not show signs of instability after the stability tests and there was a small variation in pH. The appearance has undergone minimal consistency changes. The characterization of the essential oil showed contents of 43.50% of menthol and 24.07% of menthone, being the two most relevant markers. It can be concluded that the lipsticks and lip balm remained stable and with minimal pH changes. The results obtained are promising for the development of pharmaceutical formulations for topical lip use using essential oils in their composition.