Utilização de fibrina rica em plaquetas para fins regenerativos na odontologia : uma revisão de literatura.

Abstract

Tissue engineering has been an emerging area in medical biotechnology, through research into biomaterials capable of influencing tissue regeneration. For this purpose, platelet-rich fibrin (PRF) is being considered as a promising biomaterial for use in dentistry. The present work aims to analyze the dental use of PRF and its derivative for regenerative purposes of bone tissue and soft tissues adjacent to teeth, in the following areas: periodontics, implant dentistry and minor oral surgery. For this, a literature review was carried out, using the databases: Portal Periódicos da CAPES, Medline, Google Scholar, Pubmed and Scielo, as well as classic books related to the topic, excluding scientific articles regarding the technique applied in endodontics and aesthetics. Autologous PRF is a biomaterial derived from the patient's own blood. It can be presented in coagulated or liquid form, being effective and safe to accelerate the natural tissue healing process, induce tissue regeneration through the release of growth factors by platelets, promote angiogenesis, have antimicrobial action, a good cost-benefit, it is easy to obtain and prepare, in addition to increasing its potential when associated with bone grafts. PRF has no contraindications and disadvantages, having as main indications, osteointegration procedures, maxillary sinus elevation, filling of cystic and alveolar cavities after tooth extraction or avulsion, ROG, RTG, and soft tissue management as coverage of connective tissue donor areas.