Engenharia tecidual aplicada à odontologia : estado da arte.

Abstract

Tissue engineering is an interdisciplinary field that combines the principles of biomaterials engineering and biological sciences toward the development of therapeutic strategies and biological substitutes that restore, maintain, replace or improve biological functions. Tissue engineering is considered as a triad, in which are present stem cells, extracellular matrix protein and morphogenic signals. Combining these three factors with vascular supply, the interactions between the molecules of the extracellular matrix protein and stem cells will provide the design basis for translating basic science into real components developed from this triad, in order to construct a favorable structure for the regeneration of injured tissues, thus guiding a new frontier for modern dentistry. The objective of this study is to present the principles underlying tissue engineering triad and the current scenario, the challenges and the perspectives of this area in Dentistry. The growth of tissue engineering as a research field has provided a novel set of therapeutic strategies for biomedical applications, indeed, the tissue engineering may lead to new strategies for the clinical management of patients with dental and craniofacial needs in the future.